Endocrine Abstracts

Background: Previously, we showed that thyroid hormone (TH) supplementation reduced hepatosteatosis in patients with non-alcoholic fatty liver disease (NAFLD) and was more effective in older patients. We hypothesized that intrahepatic TH concentrations may decrease with age. To investigate this issue, we examined the effects of age on intrahepatic TH concentrations in a mouse model of NAFLD.Methods: Intrahepatic TH levels and deiodinase activity were mea...

Objective: Visceral adipose tissue (VAT) and liver fat content are associated with insulin resistance and cardiovascular disease and show clear sex differences. Our objective is to determine the effect of estradiol and testosterone on VAT and liver fat content in trans women (assigned male at birth, identify as female) and trans men (assigned female at birth, identify as male).Design: Open-label partly randomized intervention study in 8 trans women and 1...

Innate immune cells, including macrophages, are functionally affected by thyroid hormone (TH). Macrophages can undergo phenotypical alterations, shifting between pro-inflammatory (M1) and anti-inflammatory (M2) profiles. Previous studies have established that increased TH concentrations shift macrophages into a more pro-inflammatory phenotype. Cellular TH concentrations are, in part, determined by TH transporters, cellular gateways facilitating bidirectional TH transport. An i...

Objectives: Congenital hypothyroidism (CH) is an inborn thyroid hormone (TH) deficiency mostly caused by disturbances at the thyroid level (thyroidal CH, CH-T). Less frequently, but equally important, CH can be the result of hypothalamic/pituitary dysfunction (central CH, CH-C). Most CH newborn screening (NBS) programs are based on the measurement of thyroid-stimulating hormone (TSH), thereby only detecting CH-T. The Dutch NBS detects CH by measuring total T4 concentrations in...